Abstract Iceland offers a favourable opportunity to examine the suggested relationship between canine distemper and multiple sclerosis. Publication types Research Support, U. Gov't, Non-P. Despite the absence of infiltrating lymphocytes and macrophages, a massive appearance of p75 NTR -positive Schwann-like cells and BSpositive microglia was noticed at 10 days in vitro. It is concluded that axonal damage as an early signal triggers the differentiation of tissue-resident precursor cells into p75 NTR -expressing aldynoglial Schwann cells that retain an immature pre-myelin state.
Further studies have to address the role of microglia during this process and the regenerative potential of aldynoglial cells in CDV infection and other demyelinating diseases. The questionnaire also obtained demographic information, residential, occupational, reproductive, and medical history, family history of disease, and multiple sclerosis data.
Associations with serum antibodies to measles virus MV and canine distemper virus CDV were evaluated, while attempting to minimize the possibility of cross-reactivity. Two peptides were synthesized for each virus, using deduced amino acid sequences from segments of the hemagglutinin protein. The peptides were selected based on sequence heterogeneity between the two viruses and hydrophilicity. Negative control antisera rabbit anti-measles for the distemper-origin peptides had higher absorbance values than the corresponding positive control antisera dog anti-distemper.
We were unable to reproduce work by other investigators showing that the two CDV peptides minimized the possibility of measuring cross-reactive serum MV antibody instead of CDV antibody.
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Subject epidemiology.
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